Why you need to know about this amazing octapeptide
We start to get expression wrinkles from about the age of 30, especially in locations where there are repeated facial movements such as around the mouth (laughter lines), worry lines on the forehead and around the eyes (crows’ feet).
Wrinkles start with the neuromuscular junction, and they’re formed by repeated muscular contraction, which results in continued skin tension. This continued tension is responsible for the formation of expression wrinkles. For muscles to contract, a neuromuscular transmitter called acetylcholine must be released. Excessive levels of acetylcholine overstimulate facial muscles and this overstimulation creates excess tension.
Let’s get technical
For wannabe scientists, this is good intel: Every time you produce an expression wrinkle, a protein called Snap 25 binds to two other proteins –VAMP(synaptobrevin) and Syntaxin – forming what’s called the SNARE complex. The primary role of the SNARE complex is to mediate docking and fusion of synaptic vesicles with the presynaptic membrane in neurons. This allows aceytlcholine to be secreted from the vesicle through a process called exocytosis. Once expelled, acetylcholine diffuses across the synaptic cleft, binding to receptors on a muscle cell membrane and in turn initiating a sequence of steps ending in muscle contraction.
What if we told you it IS possible to prevent exocytosis
Yep, the tell-tale signs of age CAN be reversed.
Up until recently, neuromodulator injectables such as Botox and Dysport have been the most effective and commonly administered compounds to blitz wrinkles. Both are types of botulinum toxin, a protein produced by the bacteria Clostridium Botulinum, which is thought to be the most lethal substance on a weight basis (1g of toxin could kill one million people). Due to its high toxicity, injection wrinkle busters must be administered by a professional under strict control.
Injectables work by cleaving the Snap 25 protein- cutting the end off- meaning that the SNARE complex cannot form. Without the SNARE complex vesicle docking and fusion cannot occur and acetylcholine cannot be released. No acetylcholine means no muscle contraction. While the injectable quick fix may sound wonderful it is not without risk or possible side effects, including pain, redness, infection, bruising, swelling, muscle stiffness, headache, drooping eyes and mouth………….the list goes on.
Now there is an even safer and cheaper alternative to injectables
Dubbed ‘The new Botox’, anti-ageing octapeptide SNAP-8™ is the newest form of anti-aging peptide Argireline. SNAP-8™ is composed of a chain of eight amino acids and applied topically via creams and serum. It’s recognised as a safer and cheaper alternative to injectables due to its main function – to disrupt neuronal exocytosis. It targets the same wrinkle formation mechanism as Botox and Dysport, but in a very different way.
SNAP-8™ works in harmony with your body
SNAP-8™ is biomimetic, which means it mimics the body’s natural function. Rather than cleaving the SNAP 25 protein, SNAP-8™ competes with it for a position in the SNARE complex. When SNAP-8™ replaces SNAP 25 the SNARE complex becomes destabilized and exocytosis cannot occur. Where anti-wrinkle injectables paralyse muscles, SNAP-8™ you could say relaxes them. You still get some muscle movement and facial expression because SNAP 8™ does not capture every SNAP 25 protein. The end result is a softer, more natural effect.
Wrinkle volume can be reduced by 21 percent in seven days and up to 63 percent in 28 days.
Our anti-ageing moisturiser, S8-28, is formulated with SNAP-8™ Peptide Solution, and recent studies show that by reducing muscle contractions with SNAP-8™, wrinkle depth is reduced by up to 21% in the first seven days, and up to 63% in one month of treatment. Fine lines and expression wrinkles fade, and the face looks smoother. It’s perfect for mature skin and also suitable for sensitive skin.
So rather than undergoing painful injections in a surgery, our anti-ageing moisturiser, S8-28, can be applied topically in the comfort of your own home as a safer and cheaper alternative to Botox.